Base-catalyzed Intramolecular Rearrangement of Trimethylamine N-oxide
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چکیده
منابع مشابه
The Base Catalyzed Rearrangement Of
Fortimicins A (1) and B (2) are aminoglycoside antibiotics. Both compounds consist of a 6-epipurpurosamine B moiety and the aminocyclitol fortamine. Fortimicin A differs from B in having a glycyl substituent at its 4-N-position. Base catalyzed loss of glycine from the 4-amino group of 1 to give 2 and a rearrangement product, 2'-N-glycylfortimicin B or isofortimicin (3), has been reported by TAD...
متن کاملThe biosynthesis of trimethylamine-N-oxide.
Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in vitro. The additional requirement for redu...
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A method for the enantioselective, intramolecular sulfenoamination of various olefins has been developed using a chiral BINAM-based selenophosphoramide, Lewis base catalyst. Terminal and trans disubstituted alkenes afforded pyrrolidines, piperidines, and azepanes in high yields and high enantiomeric ratios via enantioselective formation and subsequent stereospecific capture of the thiiranium in...
متن کاملStructural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.
Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monooxygenase (Tmm), a bacterial flavin-containing monooxygenase (FMO), is found widespread in marine bacteria and is responsible for converting TMA to TMAO. However, the molecular mechanism of TMA oxygenation by Tmm has not been explained. Here, we determined t...
متن کاملIntramolecular general base-catalyzed ester hydrolyses by the imidazolyl group.
Intramolecular general base catalysis by the imidazolyl group was found in the hydrolyses of endo-5-[4;(5')-imidazolyl]-bicyclo[2.2.1]hept-endo-2-yl trans-cinnamate and endo-5-[4'(5')-imidazolyl]bicyclo[2.2.2]oct-endo-2-yl trans-cinnamate in which the imidazolyl and trans-cinnamoyl groups are bound in close proximity to each other by rigid bicyclic rings. The rate constants for the intramolecul...
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ژورنال
عنوان ژورنال: Journal of the Faculty of Agriculture, Kyushu University
سال: 1975
ISSN: 0023-6152
DOI: 10.5109/22878